Precision medicine in CHD: genetic variants guiding post-operative clinical management

Principle Investigator: Professor David Winlaw

Project Institution: The University of Sydney

Neonatal cardiac surgery for transposition of the great arteries (TGA) is a success story, with most babies now surviving well into adulthood with a ‘normal’ circulation. Outstanding concerns are early post-operative cardiac dysfunction and other serious complications requiring prolonged intensive care in up to a third of patients. The aim is to use patient genotype to target therapy and achieve better outcomes. The project will identify individual variation in genes associated with the development of low cardiac output, and length of intensive care stay, that will form the basis of a personalised approach to post-operative care.

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